Seth chastises Carlos for his poor choice of meeting place and negotiates a smaller tribute for his admission to El Rey. Carlos arrives and his bodyguards blast open the door, letting in the sunlight which kills the vampires. As vampires surround Kate and Seth, streams of morning light enter through bullet holes in the building, making the vampires back away. Scott is overwhelmed by vampires, who begin to devour him he begs for death and Kate shoots him dead in an act of mercy. Scott hits Jacob with holy water and shoots and kills him. Jacob becomes a vampire but Scott hesitates to kill him, allowing Jacob to bite him. Sex Machine mutates into a large rat-like creature and attacks Seth but is killed. The group makes their final assault on the undead. Jacob, knowing he will soon become a vampire, makes Scott and Kate promise to kill him when he changes. In the storeroom, they fashion weapons from truck cargo the vampires have looted from past victims, including a stake mounted on a pneumatic drill, a crossbow and holy water, which requires Jacob to recover his faith to bless. Seth, Kate and Scott escape to a storeroom, followed shortly by an injured but still alive Jacob, brandishing a shotgun. Frost throws Sex Machine through the door, allowing the vampires to enter while Frost turns into a vampire. When an army of vampires, in bat form, assembles outside, the survivors lock themselves inside but Sex Machine is bitten, becomes a vampire and bites Frost and Jacob. The others are reborn as vampires, including Richie, forcing the survivors to kill them all. Only Seth, Jacob, Kate, Scott, a biker named Sex Machine and Frost - a Vietnam veteran - survive. Richie is bitten by a stripper, Santanico Pandemonium, and dies but Seth manages to kill her by shooting at a chandelier above her that impales her. When Richie complains to Seth that this is too high, Seth tells him it is non-negotiable.Дuring a bar fight, the bar employees reveal themselves as vampires and kill most of the patrons. Carlos will escort them to sanctuary at ' El Rey', a place of safety for fugitives from justice whose admission fee is 30 percent of everything they have. In Mexico, they arrive at the Titty Twister, a strip club in the desert, where the Gecko brothers will be met by their contact, Carlos, at dawn. They stop at the inn and are kidnapped by the Gecko brothers, who force the Fuller family to smuggle them over the Mexican border. Jacob Fuller, a pastor experiencing a crisis of faith brought on by the death of his wife, is on vacation with his teenage children Scott and Kate in their RV. At an inn room where they are hiding out, Seth returns from getting food to find Richie has raped and murdered a bank clerk they had taken hostage, much to his anger.

They inadvertently destroy the building as they leave. Fugitive bank robber brothers Seth and Richie Gecko hold up a liquor store, killing clerk Pete Bottoms and Texas Ranger Earl McGraw in a shootout.

The original movie dusk till dawn cast